Journal of Food, Agriculture and Environment

Vol 7, Issue 2,2009
Online ISSN: 1459-0263
Print ISSN: 1459-0255

In vivo antioxidative capacities of rapeseed meal polysaccharides


Hanju Sun *, Shaotong Jiang, Pan Mu, Ding Qi

Recieved Date: 2009-01-08, Accepted Date: 2009-03-19


In the current research, rapeseed meal was first defatted with petroleum ether and removed coloured and low molecular weight compounds with 95% (v/v) ethanol in turn. It was then extracted with 9 vol of 0.3% NaOH aqueous solution, followed by several purification steps. The resulted polysaccharides were daily administered to mice via a gastric gavage at doses of 50, 100 and 200 mgkg-1 BW, respectively, for 30 days. Vitamin C and α-tocopherol were used as positive controls. After the experimental period, the in vivo antioxidative capacities of PRM were evaluated using different assays, including glutathione peroxidase (GSH-Px), catalase (CAT) and superoxide dismutase (SOD), total antioxidant capacity (T-AOC) and malondialdehyde (MDA). These antioxidant indexes were also compared with those of standard antioxidants (vitamin C and α-tocopherol). The results indicated that PRM markedly increased the activities of GSH-Px, CAT and SOD and T-AOC levels and decreased MDA levels. The findings suggest that PRM have strong in vivo antioxidant capacities and may be recommended as health food in the future.


Rapeseed meal, polysaccharide, mice, in vivo, antioxidative capacity

Journal: Journal of Food, Agriculture and Environment
Year: 2009
Volume: 7
Issue: 2
Category: Food and Health
Pages: 97-102

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