Journal of Food, Agriculture and Environment

Vol 8, Issue 2,2010
Online ISSN: 1459-0263
Print ISSN: 1459-0255

Modulation of erythrocyte antioxidant enzyme levels by red palm oil supplementation in male Wistar rats


O. O. Oguntibeju *, E. T. Katengua, A. J. Esterhuyse, E. J. Truter

Recieved Date: 2010-01-20, Accepted Date: 2010-03-18


The depletion of antioxidants including antioxidant enzymes is known to increase the risk of complications in conditions such as cardiovascular disease, diabetes and cancer. In order to investigate such effects, a study was performed to examine the influence of red palm oil (RPO) supplementation on antioxidant enzymes in a rodent model. Male Wistar rats weighing 120-150 g were randomly divided into a control group that was fed a standard rat chow and an experimental group that received a daily dose of 2 ml of red palm oil incorporated in standard rat chow over a period of 6 weeks. Blood samples were collected from the animals at the end of the feeding period and antioxidant enzymes (superoxide dismutase (SOD), glutathione reductase (GR), catalase (CAT) and reduced glutathione (GSH) (a non-enzymatic antioxidant protein) were measured spectrophotometrically. Results showed that RPO caused a significant increase in the activities of SOD, CAT and GR but showed no observable effect on GSH. Our findings suggest that RPO could minimize oxidative damage through its potential ability to increase antioxidant enzymes and it may therefore play a role in the prevention and treatment of oxidative injuries to cells. However, further studies are required to explore and support this hypothesis.


Oxidative stress, cardiovascular disease, red palm oil, enzymes, free radical, South Africa

Journal: Journal of Food, Agriculture and Environment
Year: 2010
Volume: 8
Issue: 2
Category: Food and Health
Pages: 250-255

Full text for Subscribers

Note to users

The requested document is freely available only to subscribers/registered users with an online subscription to the Journal of Food, Agriculture & Environment. If you have set up a personal subscription to this title please enter your user name and password. All abstracts are available for free.

Article purchasing

If you like to purchase this specific document such as article, review or this journal issue, contact us. Specify the title of the article or review, issue, number, volume and date of the publication. Software and compilation, Science & Technology, all rights reserved. Your use of this website details or service is governed by terms of use. Authors are invited to check from time to time news or information.

Purchase this Article:   20 Purchase PDF Order Reprints for 15

Share this article :