Journal of Food, Agriculture and Environment

Vol 9, Issue 2,2011
Online ISSN: 1459-0263
Print ISSN: 1459-0255

Effects of lactoferricin B and cecropin P1 on growth performance, faecal score and dry matter in weaned piglets orally challenged with enterotoxigenic Escherichia coli F4


Zhen-Ping Hou 1, Wen-Jie Wang 1*, Jing-xi Liu 1, Gang Liu 2*, Zhi-qiang Liu 2, Wolfgang B. Souffrant 3, Vladimir Urubschurov 3,  Jun Fan 4

Recieved Date: 2011-01-20, Accepted Date: 2011-04-08


Forty-eight German Landrace weaned pigs were used in this study to investigate the effects of Lfcin B and Cec P1 on performance, faecal score and DM of weaned piglets orally challenged with enterotoxigenic Escherichia coli F4. The piglets were assigned randomly into four groups: Control, enterotoxigenic Escherichia coli F4ac (ETEC), enterotoxigenic Escherichia coli F4ac (ETEC)+lactoferricin B (Lfcin B) and enterotoxigenic Escherichia coli F4ac (ETEC) +Cecropin P1 (Cec P1) on the basis of weight and litter. All piglets in three experimental groups were orally challenged with 3×109 cfu E.coli K88 O149:K91:F4ac on d 29 and 30. Lfcin B and Cec P1 were administered orally as a single dose of 2 mg per piglet on d 29 after being challenged ETEC F4ac 3 hours later. From the age of 30 days, the piglets were offered feed and water ad libitum. The results showed that there were no significant differences on daily weight, ADG and ADFI (P>0.05) of piglets among the four groups during the experimental period. From d 28 to 35, the piglets in Cec P1 groups kept higher daily weight (p>0.05) than those in other three groups. There were no differences for faecal score and feces dry matter among the four groups. But there was a tendency piglet in Cec P1 group kept the balance of faecal score and feces dry matter. Though there are no obvious effects, Lfcin B and Cec P1 have potential use without toxicity in vivo as additive in the husbandry product.


Enterotoxigenic Escherichia coli F4ac, piglets, lactoferricin B, cecropin P1

Journal: Journal of Food, Agriculture and Environment
Year: 2011
Volume: 9
Issue: 2
Category: Agriculture
Pages: 275-280

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