Journal of Food, Agriculture and Environment

Distribution and excretion of the PEGylated recombinant new human interleukin-6 (PEG-rhIL-6) in rats

Author(s):

Zhen-hua Wang ^{1, 2}, Shu-fang Wang ³, Xiao-gang Du ¹, Zhi-yu Chen ¹, Xiaohan Cao ¹, Xian-yin Zeng ^1*

Recieved Date: 2011-05-26, Accepted Date: 2011-10-06

Abstract:

The distribution and excretion of ¹²⁵I-PEG-rhIL-6 in rats were investigated by ¹²⁵I isotope tracing method. Results showed that the concentration in the brain is lowest and highest in plasma 8 h post-injection. The results indicated that the blood was the main site of action of ¹²⁵I-PEG-rhIL-6, which provides a basis for PEG-rhIL-6 treating of thrombocytopenia.

Keywords:

Interleukin-6, excretion, distribution, isotope tracing

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Journal: Journal of Food, Agriculture and Environment
Year: 2011
Volume: 9
Issue: 3&4
Category: Food and Health
Pages: 68-71

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