Journal of Food, Agriculture and Environment

Vol 9, Issue 3&4,2011
Online ISSN: 1459-0263
Print ISSN: 1459-0255

Distribution and excretion of the PEGylated recombinant new human interleukin-6 (PEG-rhIL-6) in rats


Zhen-hua Wang 1, 2, Shu-fang Wang 3, Xiao-gang Du 1, Zhi-yu Chen 1, Xiaohan Cao 1, Xian-yin Zeng 1*

Recieved Date: 2011-05-26, Accepted Date: 2011-10-06


The distribution and excretion of 125I-PEG-rhIL-6 in rats were investigated by 125I isotope tracing method. Results showed that the concentration in the brain is lowest and highest in plasma 8 h post-injection. The results indicated that the blood was the main site of action of 125I-PEG-rhIL-6, which provides a basis for PEG-rhIL-6 treating of thrombocytopenia.


Interleukin-6, excretion, distribution, isotope tracing

Journal: Journal of Food, Agriculture and Environment
Year: 2011
Volume: 9
Issue: 3&4
Category: Food and Health
Pages: 68-71

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