Journal of Food, Agriculture and Environment

Vol 9, Issue 3&4,2011
Online ISSN: 1459-0263
Print ISSN: 1459-0255

Hydroxytyrosol and oleuropein from olive leaves: Potent anti-inflammatory and analgesic activities


Ehsen Haloui 1, Belsem Marzouk 2, Zohra Marzouk 1*, Abderrahman Bouraoui 3, Nadia Fenina 1

Recieved Date: 2011-06-05, Accepted Date: 2011-09-22


The goal of this study was to evaluate the analgesic and the anti-inflammatory activities of two polyphenols rich olive leaves extracts. At the tested doses (100, 200 and 300 mg/kg), Oleuropein – Rich Olive Extract (ORE) and Hydroxytyrosol – Rich Olive Extract (HRE) inhibited, significantly, writhing and reduced carrageenan-induced hind paw edema in a dose dependent manner. HRE was more effective than ORE to relieve inflammation and nociception. In addition, the acute toxicity test showed that ORE and HRE did not present acute toxicity up to a maximum dose of 1000 mg/kg.


Olea europaea L. cv. Chemlali, anti-inflammatory activity, analgesic activity, oleuropein, hydroxytyrosol, paw oedema, writhing test

Journal: Journal of Food, Agriculture and Environment
Year: 2011
Volume: 9
Issue: 3&4
Category: Food and Health
Pages: 128-133

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