Journal of Food, Agriculture and Environment

Vol 9, Issue 3&4,2011
Online ISSN: 1459-0263
Print ISSN: 1459-0255

Lipid-lowering evaluation of cold-pressed Camelina sativa oil


Qianchun Deng, Fenghong Huang *, Qingde Huang, Jiqu Xu, Changsheng Liu

Recieved Date: 2011-08-20, Accepted Date: 2011-10-04


The objective of the present study was to investigate the impact of increasing doses of cold-pressed Camelina sativa oil (CO) with high level of α- linolenic acid (56.1%) on plasma and liver lipids as well as on oxidative level of Sprague-Dawley rats fed with high fat diets (HFD) containing 20% fat and 1% cholesterol. The effect of 1.1, 2.2 and 4.4 g/kg b.w. CO were studied with 2.2 g/kg b.w. fish oil as positive control. After six weeks, 4.4 g/ kg b.w. CO and 1.1 g/kg b.w. fish oil significantly lowered the increase of body weight gain, liver weight gain, total cholesterol (TC) and total triglyceride (TG) in liver and plasma, (low degree lipoprotein + very low degree lipoprotein)-cholesterol [(VLDL+LDL)-C] and aspartate amino transferase (AST) in plasma resulted from high-fat diets (P < 0.05), in which CO acted in a dose-dependent manner. The increase of plasma high degree lipoprotein 3 (HDL3) and plasma lipoprotein displacement in agarose gel electrophoresis of high-fat diet fed rats ingested CO also showed that CO could promote the metabolism of HDL subset to miniaturize the HDL particles. Liver protection by CO was further substantiated by the improved liver histological findings in HFD fed rats. However, fish oil and CO did not have effect on decreased antioxidation level resulted from high-fat diets. These data suggest that CO participates in the normal regulation of plasma lipid concentration and cholesterol metabolism in the liver. Thus, Camelina sativa oil containing a high level of α-linolenic acid possesses lipid-lowering activity by regulating the blood lipid metabolism and protecting liver function.


Cold-pressed Camelina sativa oil, α-linolenic acid, lipid-lowering activity, high fat diets, Sprague-Dawley rats

Journal: Journal of Food, Agriculture and Environment
Year: 2011
Volume: 9
Issue: 3&4
Category: Food and Health
Pages: 157-162

Full text for Subscribers

Note to users

The requested document is freely available only to subscribers/registered users with an online subscription to the Journal of Food, Agriculture & Environment. If you have set up a personal subscription to this title please enter your user name and password. All abstracts are available for free.

Article purchasing

If you like to purchase this specific document such as article, review or this journal issue, contact us. Specify the title of the article or review, issue, number, volume and date of the publication. Software and compilation, Science & Technology, all rights reserved. Your use of this website details or service is governed by terms of use. Authors are invited to check from time to time news or information.

Purchase this Article:   20 Purchase PDF Order Reprints for 15

Share this article :