Journal of Food, Agriculture and Environment

Vol 9, Issue 3&4,2011
Online ISSN: 1459-0263
Print ISSN: 1459-0255

Effect of enterotoxin on promotion of adhesion of enterotoxigenic Escherichia coli


Xue-Feng Qi 1*, Fang Wang 1, Da-Hui Wang 1, Ai-Hua Wang 1, Chun-Jiang Wang 1, Jin-Long Yang 2, Bao Zhao 1, Xian-Jun Zhao 1

Recieved Date: 2011-07-05, Accepted Date: 2011-09-26


Recent in vivo and in vitro observations suggesting a potential role for ETEC enterotoxins in initial stages of host colonization promoted us to clarify potential contributions of enterotoxins in modulating fimbrae expression at early stages of pathogen-host interactions. We used an in vitro model of ETEC adherence to quantify fimbriae and enterotoxin factors expression of porcine ETEC strains. Quantitative PCR measurement demonstrating that there is a significant difference of virulence factors expressed by ETEC strains during adhesive to intestinal cells. The levels of fimbriae expressed by ETEC strain with different phenotypes have a close correlation with strain-specific adhesive to porcine intestinal epithelial cells. Furthermore, it is interesting to note that there is a good relevancy between the levels of enterotoxin and fimbriae. Significant high levels of enterotoxin were detected in these strains that expressed high fimbrae levels synchronously. Altogether, the present study initially revealed that enterotoxin-mediated enhancement of bacterial adherence via modulation of fimbriae expression during adhesive to intestinal epithelial cells in vitro.


Immortalized porcine intestinal epithelial cells, enterotoxigenic Escherichia coli, adhesion, virulence factors expression

Journal: Journal of Food, Agriculture and Environment
Year: 2011
Volume: 9
Issue: 3&4
Category: Agriculture
Pages: 576-579

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