Journal of Food, Agriculture and Environment

Vol 10, Issue 1,2012
Online ISSN: 1459-0263
Print ISSN: 1459-0255

The influence of cigarette smoking on endothelial function


Germaine Săvoiu *, Carmen Cristescu, Claudia Borza, Mihaiela Andoni, Corina Şerban, O. Fira-Mladinescu, Daniela Chiru, Georgeta Maria Simu, Lelia Şuşan, Rodica Mateescu

Recieved Date: 2011-09-02, Accepted Date: 2012-01-06


Cigarette smoking is well recognized as a major risk factor for atherosclerosis in men and women. Brachial flow-mediated dilation (FMD) is a physiologic measure and carotid intima-media thickness (IMT) is an anatomic structural measure of subclinical atherosclerosis. The purpose of this study was to observe the effects of cigarette smoking expressed in package-years on endothelial function evaluated by ultrasonographic measurement of brachial FMD and carotid IMT in four groups of subjects: arterial hypertension [HTN] group, atherogenic dyslipidemia [DYS] group, coronary artery disease, angiographically confirmed [BCV] group and [CON] group. Cigarette smoking, measured in package – years was significantly higher in [BCV] group compared to the [DYS] group (p<0.001), the [HTN] group (p<0.001) and the [CON] group (p<0.001). The forearm reactive hyperemic response (FMD) was significantly blunted in [BCV] group (p<0.001) compared to [HTN] group (p<0.001), [DYS] group (p<0.001) and to [CON] group (p<0.001). The patients from [BCV] group had highly significant greater IMT compared to patients from [HTN] group, [DYS] group and [CON] group (p<0.001). In our study, we observed that cigarette smoking induces a significant deterioration of endothelial dysfunction that is dependent of the number of package-years.


Intima-media thickness, flow mediated vasodilatation, cigarette smoking, endothelial function

Journal: Journal of Food, Agriculture and Environment
Year: 2012
Volume: 10
Issue: 1
Category: Food and Health
Pages: 25-28

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