Journal of Food, Agriculture and Environment

Vol 8, Issue 3&4,2010
Online ISSN: 1459-0263
Print ISSN: 1459-0255

Colloidal competences of new tailor-made lipids


Călin Jianu *, Ionel Jianu

Recieved Date: 2010-08-14, Accepted Date: 2010-11-06


An overview on the theoretical and practical aspects which define lipids as generally basic nutritional principles, as well as the constantly increasing interest in their diversification with new representatives characterized through improved benefits for the consumers health, suggested the idea of realization of “hybrid lipids” (“tailor-made lipids”) PEGn-[2R’; R (LM; CS)] and PEGn-[R’; 2R (LM; CS)] conjugated through PEGylation. PEGylation presupposes the derivatization of certain “homogeneous” polyoxyethylenic chains with degrees of oligomerization n=3, 9, 18 [processed by the adapted method of Williamson, then purified and characterized chemically and physico-chemically (colloidally)] with hydrocarbonate chains R [C12H25/C14H29 (7/3) -lauryl/miristyl (7/3) (LM) or C16H33C18H37(7/3)-cetyl/stearyl (7/3) (CS), respectively] and hydrocarbonate chains R’ from polyunsaturated fatty acids, which were then isolated, purified and characterized gas-chromatographically, from saponifiable fractions of grape seeds (fruits) (Vitis vinifera) (R’s) [C16(0∆) 10.10%; C18(1∆) 24.80%; C18(2∆) 64.90%], horse chestnuts (Aesculus hippocastanum) (R’ca) [C16(0∆) 10.90%; C18(1∆) 57.00%; C18(2∆) 28.80%; C18(3∆) 3.72%], wild rose hips (Rosa canina) (R’m) [C16(0∆) 3.19%; C18(1∆) 15.92%; C18(2∆) 67.50%; C18(3∆) 13.30%] and coriander fruits (Coriandrum sativum) (R’co) [C16(0∆) 2.70%; C18 (1∆) 83.00%; C18 (2∆) 13.40%].The esterification of the mono- or diprotected glycerine by selective acylation in molar ratio R’/R = 1/2 and R’/R = 2/1, respectively, has enabled preparation of a series of 48 conjugates PEGn-L (2R’; R) (R’; 2R) which were purified and afterwards characterized physico-chemically (colloidally).


PEGylated lipids, monovesicles, tailor-made lipids, polyethylene glycol (PEG), substituted, poly(ethylene glycol)-lipid conjugates, liposome

Journal: Journal of Food, Agriculture and Environment
Year: 2010
Volume: 8
Issue: 3&4
Category: Food and Health
Pages: 148-155

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