Journal of Food, Agriculture and Environment

Colloidal competences of new tailor-made lipids

Author(s):

Călin Jianu *, Ionel Jianu

Recieved Date: 2010-08-14, Accepted Date: 2010-11-06

Abstract:

An overview on the theoretical and practical aspects which define lipids as generally basic nutritional principles, as well as the constantly increasing interest in their diversification with new representatives characterized through improved benefits for the consumers health, suggested the idea of realization of “hybrid lipids” (“tailor-made lipids”) PEG_n-[2R’; R (LM; CS)] and PEG_n-[R’; 2R (LM; CS)] conjugated through PEGylation. PEGylation presupposes the derivatization of certain “homogeneous” polyoxyethylenic chains with degrees of oligomerization n=3, 9, 18 [processed by the adapted method of Williamson, then purified and characterized chemically and physico-chemically (colloidally)] with hydrocarbonate chains R [C₁₂H₂₅/C₁₄H₂₉ (7/3) -lauryl/miristyl (7/3) (LM) or C₁₆H₃₃C₁₈H₃₇(7/3)-cetyl/stearyl (7/3) (CS), respectively] and hydrocarbonate chains R’ from polyunsaturated fatty acids, which were then isolated, purified and characterized gas-chromatographically, from saponifiable fractions of grape seeds (fruits) (Vitis vinifera) (R’s) [C₁₆(0∆) 10.10%; C₁₈(1∆) 24.80%; C₁₈(2∆) 64.90%], horse chestnuts (Aesculus hippocastanum) (R’ca) [C₁₆(0∆) 10.90%; C₁₈(1∆) 57.00%; C₁₈(2∆) 28.80%; C₁₈(3∆) 3.72%], wild rose hips (Rosa canina) (R’m) [C₁₆(0∆) 3.19%; C₁₈(1∆) 15.92%; C₁₈(2∆) 67.50%; C₁₈(3∆) 13.30%] and coriander fruits (Coriandrum sativum) (R’co) [C₁₆(0∆) 2.70%; C₁₈ (1∆) 83.00%; C₁₈ (2∆) 13.40%].The esterification of the mono- or diprotected glycerine by selective acylation in molar ratio R’/R = 1/2 and R’/R = 2/1, respectively, has enabled preparation of a series of 48 conjugates PEG_n-L (2R’; R) (R’; 2R) which were purified and afterwards characterized physico-chemically (colloidally).

Keywords:

PEGylated lipids, monovesicles, tailor-made lipids, polyethylene glycol (PEG), substituted, poly(ethylene glycol)-lipid conjugates, liposome

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Journal: Journal of Food, Agriculture and Environment
Year: 2010
Volume: 8
Issue: 3&4
Category: Food and Health
Pages: 148-155

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