Journal of Food, Agriculture and Environment

Vol 10, Issue 3&4,2012
Online ISSN: 1459-0263
Print ISSN: 1459-0255

Effect of dietary L-arginine supplementation on edema disease


Wenkai Ren 1, 4, Tiejun Li 1, 3 *, Hua Shao 1, 4 *, Yinghui Li 1, 4, Gang Liu 1, Li Wu 1,4, Miaomiao Wu 1, 4, Xiaosong Wu 2*

Recieved Date: 2012-06-19, Accepted Date: 2012-09-29


The purpose of this study was to test the hypothesis that the dietary L-arginine supplementation has beneficial effects on edema disease. Experimental animals were 156 KunMing mice, randomly assigned to arginine group 1 (0.6% arginine + basal diet, n = 44), arginine group 2 (0.6% arginine + basal diet, n = 44), control group 1 (1.22% alanine + basal diet, n = 34) and control group 2 (1.22% alanine + basal diet, n = 34). After 3 days of adaptive feeding and a 7 days treatment period with the prepared feed, all mice were challenged by intraperitoneal injection of Escherichia coli O139 (E.coli) at LD50 (2.53 × 108 CFU/ml). Arginine group 2 and control group 2 were used to calculate the mortality after twenty hours of injection. Serum concentrations of platelet- activating factor (PAF), interleukin (IL)-2, interleukin (IL)-10, secretory immunoglobulin A (sIgA), superoxide dismutase (SOD) activity, total antioxidant capacity (T-AOC), cyclic 3',5'-adenosinemonophosphate (cAMP) and cyclic 3',5'-guanosine monophosphate (cGMP) were measured in arginine group1 and control group1 in a ten-hour interval for three times. The serum concentration of PAF was much lower (P < 0.01) in arginine group than in alanine group in all the time. Additionally, T-AOC and SOD activity in the experiment group increased significantly (P < 0.05) in the first ten hours after initial injection. Unfortunately, T-AOC and SOD activity in arginine group became quiet (P > 0.05) compared to the control group after that, except T-AOC was greater (P < 0.05) in arginine group than in the control group in twenty hours of initial injection. Meanwhile, arginine supplementation had little effect on the mortality of mice, serum IL-2, sIgA, cAMP and cGMP level. In conclusion, dietary arginine supplementation can partially attenuate the damage caused by edema disease, but have little effect on the clinical results. 


Arginine, edema disease, Escherichia coli, platelet-activating factor

Journal: Journal of Food, Agriculture and Environment
Year: 2012
Volume: 10
Issue: 3&4
Category: Agriculture
Pages: 630-634

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