Journal of Food, Agriculture and Environment

Vol 11, Issue 1,2013
Online ISSN: 1459-0263
Print ISSN: 1459-0255

Antihypertensive effect of angiotensin-converting enzyme inhibitory peptides from silver carp (Hypophthalmichthys molitrix) hydrolysate in spontaneously hypertensive rats


Jin-Chao Wu *, Xiao-Lai Shi, Miao Yu

Recieved Date: 2012-10-10, Accepted Date: 2013-01-24


In order to utilize silver carp (Hypophthalmichthys molitrix), which is abundant and very cheap fresh-water fish in China, defatted silver carp muscle was hydrolysed by compound protease to achieve angiotensin-converting enzyme (ACE) inhibitory peptides. The protein hydrolysates were fractionated into low and high molecular weight fractions using an ultrafiltration (UF) membrane system. The ACE-inhibitory activity tests showed that the low molecular weight fraction was more effective. Most of the peptides in low molecular weight fraction ranged from 600 to 1600 Da. Anti-hypertensive effects of silver carp ACE-inhibitory peptides on spontaneously hypertensive rats (SHR) following oral administration was determined as the tail systolic blood pressure significantly decreased after peptides ingestion.


Silver carp, Hypophthalmichthys molitrix, ACE inhibitory peptide, antihypertensive effect

Journal: Journal of Food, Agriculture and Environment
Year: 2013
Volume: 11
Issue: 1
Category: Food and Health
Pages: 118-120

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