Journal of Food, Agriculture and Environment

Antihypertensive effect of angiotensin-converting enzyme inhibitory peptides from silver carp (Hypophthalmichthys molitrix) hydrolysate in spontaneously hypertensive rats

Author(s):

Jin-Chao Wu *, Xiao-Lai Shi, Miao Yu

Recieved Date: 2012-10-10, Accepted Date: 2013-01-24

Abstract:

In order to utilize silver carp (Hypophthalmichthys molitrix), which is abundant and very cheap fresh-water fish in China, defatted silver carp muscle was hydrolysed by compound protease to achieve angiotensin-converting enzyme (ACE) inhibitory peptides. The protein hydrolysates were fractionated into low and high molecular weight fractions using an ultrafiltration (UF) membrane system. The ACE-inhibitory activity tests showed that the low molecular weight fraction was more effective. Most of the peptides in low molecular weight fraction ranged from 600 to 1600 Da. Anti-hypertensive effects of silver carp ACE-inhibitory peptides on spontaneously hypertensive rats (SHR) following oral administration was determined as the tail systolic blood pressure significantly decreased after peptides ingestion.

Keywords:

Silver carp, Hypophthalmichthys molitrix, ACE inhibitory peptide, antihypertensive effect

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Journal: Journal of Food, Agriculture and Environment
Year: 2013
Volume: 11
Issue: 1
Category: Food and Health
Pages: 118-120

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