Journal of Food, Agriculture and Environment




Wound healing potential of methanolic extracts of some plants native to Al-Qassim Region, Saudi Arabia


Author(s):

Khaled B. Al-Harbi*, E.A. El-Tigani-Asil, Ahmed F. Ahmed, Ibrahim M. El- Ashmawy, Naser A. Al-Wabel

Recieved Date: 2016-05-15, Accepted Date: 2016-09-12

Abstract:

Folklone phytotherapy is a worldwide practice extensively used for the treatment of various conditions like wounds which are rising as one of the health care obstacles. This study was undertaken to evaluate wound healing effect of methanolic extracts of some plants native to Al-Qassim Region, Saudi Arabia. Wistar rats were used as an animal model for the experiment. Qualitative and quantitative screening of the extracted phytoconstituents were done using standard procedures. A formula of soft paraffin-based ointment (10% conc.) of each crude extract was prepared and used to test wound healing effect in the incision and excision wounded rat models. Wound healing response assessment using inflammation, granulation, regeneration, wound contraction, clossuring rate and reepithelialization parameters were adopted. Phytochemical analysis showed flavonoids, tannins and saponins with various amounts. Healing response signs; viz., inflammation, granulation, regeneration, wound contraction and re-epithelialization were observed in the skin sections of sacrified animals. Extracts of Heliotropium bacciferum, Rhanterium epapposum, Achillea fragrantissima, Artemisia herba alba, Haloxylon salicornicum, Deverra triradiata, Echinops hussoni, Prosopis farcta, Cyperus conglomeratus and Astragalus spinosus were the most potent wound healers that showed complete wound contraction surface (P≤0.05) by the end of the experiment and this may possible due to its high contents of the phytoconstituents.This study concluded that some plant extracts have potential wound healing effect and further investigations are needed to obtain complete profile and its various actions.

Keywords:

Wound healing, methanolic plant extracts, phytoconstituents


Journal: Journal of Food, Agriculture and Environment
Year: 2016
Volume: 14
Issue: 3&4
Category: Food and Health
Pages: 18-22


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