Journal of Food, Agriculture and Environment

Biochemical and hematologic changes related to administration of double doses of non-ionic contrast medium Iomeron 350 (iomeprol) in cats

Author(s):

Radu Lăcătuş ¹, Robert Cristian Purdoiu ¹, Liviu Bogdan ¹*, Sidonia Bogdan ¹, Ramona Jurcău ², Ionel Papuc ¹

Recieved Date: 2013-06-10, Accepted Date: 2013-10-28

Abstract:

To monitor the effects of double doses of non-ionic contrast substance administered via i.v. to cats, on the major function and the biochemical and hematological parameters, one non-ionic contrast substance was tested (Iomeron 350) on 15 adult cats both male and female.The administered dose was of 2.3 ml/kg, the normal dose recommended for cats is 1-1.3 ml/kg. Several biochemical and hematological parameters were determined before the administering of Iomeron 350, 5 min, 60 min and 24 h after the non-ionic contrast substance was administered. High values of glucose (GLU), gamma glutamic transferase (GGT), total bilirubin (TBIL) and direct bilirubin (DBIL) were identified. Repeated measurement by ANOVA testing shows a statistically significant measures at 5 min and 60 min for GLU and GGT (P<0.0001) and statistically significant differences at 24 h for TBIL and DBIL (P<0.0001). The other biochemical parameters studied showed an increasing trend at 5 and 60 min after the non-ionic contrast substance administration, but the values were within normal ranges. Twenty four hours after the Iomeron 350 administration, the biochemical parameters, except TBIL and DBIL, showed a decreasing trend toward normal values. Hematological values did not show significant increase after double doses of contrast media. The effect on the liver and kidneys was minimal, no morphological or functional changes were noticed and the life of the subjects was not threatened.

Keywords:

Non-ionic contrast substance, cats, biochemical and hematological changes, double dose

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Journal: Journal of Food, Agriculture and Environment
Year: 2013
Volume: 11
Issue: 3&4
Category: Food and Health
Pages: 214-216

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