Journal of Food, Agriculture and Environment

Endocrine-disrupting potential of arsenic on reproductive and other metabolic hormones


Geetika Saini, Disha Chauhan, Sunil Kumar, Ranjit Kumar

Recieved Date: 2022-01-13, Accepted Date: 2022-03-21


Arsenic is a metalloid found in the earth’s crust; it may lead to many health issues but its endocrine disrupting nature is less studied on the reproductive system. It acts on pancreatic hormones and mimics their action by altering hormone-binding as well as down-regulation of hormonal signals. Research papers on the effect of arsenic and hormonal imbalances are studied and information obtained was used in this review paper. Arsenic mimics the effect of estradiol hormone, decreases ERaexpression,and increases progesterone receptor’s expression. It also decreases prolactin level which impairs foetal growth in the second and third trimesters. Increased progesterone may interfere with an increased level of estrogen leading to anomalies in ovulation. It can lead to impaired implantation leading to miscarriage.Arsenic affects hypothalamus-pituitary homeostasis which decreases the negative feedback system on the release of female sex hormones leading to female infertility. Arsenic also decreases testosterone level leading to azoospermia. It causes a decrease in LH and FSH levels which adversely affects spermatogenesis. It causes infertility in both males and females. Arsenic decreases insulin secretion and is associated with adverse pregnancy outcomes. It was noted that arsenic causes impaired male and female hormone imbalances leading to infertility and causes the generation of oxidative stress, which is one of the possible mechanisms for arsenicinduced carcinogenesis.


ACTH, ERa, FSH, hormone-binding, LH, miscarriage

Journal: Journal of Food, Agriculture and Environment
Year: 2022
Volume: 20
Issue: 2
Category: Food and Health
Pages: 43-51

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