Journal of Food, Agriculture and Environment




Vol 18, Issue 3&4,2020
Online ISSN: 1459-0263


Potency of jack bean (Canavalia ensiformis (L.) DC) and red kidney bean (Phaseolus vulgaris L.) extracts as antidiabetic agents


Author(s):

Anita Maya Sutedja, Dedi Fardiaz, Irmanida Batubara, Hanifah Nuryani Lioe, Tohru Mitsunaga, Dahrul Syah, Emiko Yanase

Recieved Date: 2020-07-04, Accepted Date: 2020-09-19

Abstract:

Phenolics, occurred as secondary metabolites in jack bean (Canavalia ensiformis (L.) DC) and red kidney bean (Phaseolus vulgaris L.), could offer potential health benefits primarily in reducing the risk of several chronic diseases, such as diabetes. This research was aimed to investigate the potential antidiabetic properties generated by the bean extracts. The extraction was carried out using ethanol and methanol continuously, as well as using water as a sequence of methanol extraction. The methanol extracts of both beans showed the highest total phenolic content (TPC), followed by water and ethanol extracts. Although TPC was relatively high in all extracts, flavonoid was only present in ethanol and methanol extracts of both beans. The total flavonoid contents (TFC) of all methanol extracts were higher than their respective ethanol extracts. The DPPH scavenging activity and in vitro α-glucosidase inhibition activity of the methanol extracts were found to be higher than those of ethanol extracts, thus their IC50 showed the lower concentrations compared to ethanol extracts. Principal Component Analysis (PCA) described the potency of methanol extracts as antidiabetic agents due to the positive correlation to TPC and TFC, and to the low IC50 values according to DPPH scavenging activity and αglucosidase inhibition activity.

Keywords:

Antidiabetic,  antioxidant, α-glucosidase inhibition, total flavonoid, total phenolic


Journal: Journal of Food, Agriculture and Environment
Year: 2020
Volume: 18
Issue: 3&4
Category: Food and Health
Pages: 36-42


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