Journal of Food, Agriculture and Environment

Vol 5, Issue 3&4,2007
Online ISSN: 1459-0263
Print ISSN: 1459-0255

Factors affecting growth and antifungal activity of some Streptomyces species against Candida albicans


Mohamed Rizk 1*, Tahany Abdel-Rahman 1, Hanaa Metwally 2

Recieved Date: 2007-04-15, Accepted Date: 2007-07-27


The present study was carried out to investigate the physical and nutritional factors affecting the growth and antifungal activity of three Streptomyces species (S. fradiae, S. lavendulae and S. fulvissimus) against C. albicans. Starch was the best carbon source for all Streptomyces spp., whereas the other tested C-sources gave varying amounts of growth and antifungal activity. Addition of mannitol to the media as sole C-source inhibited growth and antifungal activity of both S. fradiae and S. lavendulae. Potassium nitrate followed by peptone, NH4H2PO4 and NH4NO3 were the most suitable N-sources in case of S. fradiae, whereas Ca(NO3)2, NH4NO3 and peptone were the best N-sources for the other two species. Maximum antifungal activity was recorded at starch:KNO3 ratio 1:1, incubation temperature 30ºC and pH 7. This activity was completely inhibited at low temperatures (5-15ºC) and pH 4 in the tested species.


Streptomyces, Candida albicans, physical and nutritional factors, antifungal activity

Journal: Journal of Food, Agriculture and Environment
Year: 2007
Volume: 5
Issue: 3&4
Category: Environment
Pages: 446-449

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