Journal of Food, Agriculture and Environment

Vol 10, Issue 2,2012
Online ISSN: 1459-0263
Print ISSN: 1459-0255

Dietary supplementation with arginine and glutamine confers a positive effect in porcine circovirus-infected pig


Wenkai Ren 1, 3, Gang Liu 1, Teijun Li 1, Jie Yin 2, 5, Xiaosong Wu 5, Meimei Geng 1*, Wei Luo 4, Ruan Zheng 2, Xinglong Yu 4

Recieved Date: 2012-01-16, Accepted Date: 2012-05-05


This study was conducted to test the hypotheses that dietary arginine and glutamine supplementation may confer beneficial effect on porcine circovirus type 2 (PCV2)-infected pigs. The measured variables included: 1) average daily weight gain (ADG), feed conversion rate (FCR); 2) PCV2 virus load in the submaxillary lymph node, spleen, liver, kidney and heart at 20 days post infection (DPI); 3) microscopic lesions in the spleen at 20 DPI; 4) serum cytokine levels, serum antioxidant capacity (T-AOC, T-SOD and GSH-PX), serum PCV2 virus load, serum nitric oxide (NO) and serum PCV2 antibody titers at 5, 10, 15 and 20 DPI. Dietary arginine and glutamine supplementation conferred positive effect on the production of PCV2 infected pigs. Meanwhile, arginine and glutamine supplementation increased the antioxidant capacity and immune response, and decreased the PCV2 virus load in tissue. Moreover, these beneficial effects may be mainly performed through NO. It was concluded that dietary arginine and glutamine supplementation confers positive effect on the PCV2 infected pigs. 


Pigs, porcine circovirus, arginine, nutrition, amino acids, glutamine, antioxidant capacity

Journal: Journal of Food, Agriculture and Environment
Year: 2012
Volume: 10
Issue: 2
Category: Agriculture
Pages: 485-490

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