Journal of Food, Agriculture and Environment

Vol 12, Issue 2,2014
Online ISSN: 1459-0263
Print ISSN: 1459-0255

Assessment of proteinuria in chronic kidney disease: Urine protein excretion in twenty-four-hour collections or protein-to-creatinine ratio in spot urine samples


Alexandru Caraba 1, Corina Serban 2 *, Claudia Borza 2, Ioan Romosan 1, Romulus Timar 3

Recieved Date: 2014-01-20, Accepted Date: 2014-03-28


The aim of this study was to compare urine protein excretion in twenty-four-hour collections with total protein to creatinine ratio (PCR) in CKD patients in chronic renal diseases (CKD). The study was performed on a group of 151 CKD patients in different stages of evolution. The following parameters were obtained from each patient: proteinuria (biuret method), creatinine clearance (Jaffe method) and protein/creatinine ratio. The values of monitored parameters were: 1574.55±1219.7 mg/24 h (proteinuria), 60.62±31.72 ml/min (creatinine clearance) and 1.46±1.21 (urinary protein/creatinine ratio). It was observed a statistically significant correlation between the values of proteinuria determined in urine collected during 24 h and PCR in spot urine samples (r = 0.956475, p < 0.001). PCR in spot urine samples is a simple and safe method that could be used as an alternative to urine protein excretion in twenty-four-hour collections in CKD patients.


Chronic kidney disease, twenty-four-hour proteinuria, creatinine clearance, protein/creatinine ratio, proteinuria

Journal: Journal of Food, Agriculture and Environment
Year: 2014
Volume: 12
Issue: 2
Category: Food and Health
Pages: 11-14

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