Journal of Food, Agriculture and Environment

Antagonist of MRSA by Streptomyces sp. SJY056 from soil of the Three-river headwater region in China

Author(s):

Hongjian Zhu ^{1, 2}, Xinyu Zhou ^{1, 2}, Xianghua Lei ^{1, 2}, Qingming Zhou ^{3 *}

Recieved Date: 2013-06-20, Accepted Date: 2013-10-18

Abstract:

A total of 230 Actinomycetes were obtained from the soil of the Three-river headwater national nature reserve in Qinghai province, China. A strain, SJY056, was isolated after primary screening using a plate confrontation culture method followed by a fermentation filtrate inhibitory assay. The fermentation filtrate significantly inhibited the growth of MRSA after diluted for 5 folds with an inhibition halo of 21-mm in diameter. Results of phenotypic, physiological and biochemical analyses, as well as sequencing analysis of 16S rDNA indicated that SJY056 was a strain of Streptomyces atroolivaceus. The organic phase obtained after liquid-liquid extraction of the metabolites of SJY056 using ethyl acetate inhibited the growth ofMRSA with a inhibition halo of 23-mm in diameter, while the inorganic phase had no inhibitory effect on the growth of MRSA. These results indicated that the metabolites of SJY056 contained MRSA antagonist that had potential antibiotic activities.

Keywords:

MRSA, Actinomycetes, identification

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Journal: Journal of Food, Agriculture and Environment
Year: 2013
Volume: 11
Issue: 3&4
Category: Food and Health
Pages: 420-422

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