Journal of Food, Agriculture and Environment

Vol 11, Issue 3&4,2013
Online ISSN: 1459-0263
Print ISSN: 1459-0255

Antagonist of MRSA by Streptomyces sp. SJY056 from soil of the Three-river headwater region in China


Hongjian Zhu 1, 2, Xinyu Zhou 1, 2, Xianghua Lei 1, 2, Qingming Zhou 3 *

Recieved Date: 2013-06-20, Accepted Date: 2013-10-18


A total of 230 Actinomycetes were obtained from the soil of the Three-river headwater national nature reserve in Qinghai province, China. A strain, SJY056, was isolated after primary screening using a plate confrontation culture method followed by a fermentation filtrate inhibitory assay. The fermentation filtrate significantly inhibited the growth of MRSA after diluted for 5 folds with an inhibition halo of 21-mm in diameter. Results of phenotypic, physiological and biochemical analyses, as well as sequencing analysis of 16S rDNA indicated that SJY056 was a strain of Streptomyces atroolivaceus. The organic phase obtained after liquid-liquid extraction of the metabolites of SJY056 using ethyl acetate inhibited the growth ofMRSA with a inhibition halo of 23-mm in diameter, while the inorganic phase had no inhibitory effect on the growth of MRSA. These results indicated that the metabolites of SJY056 contained MRSA antagonist that had potential antibiotic activities.


MRSA, Actinomycetes, identification

Journal: Journal of Food, Agriculture and Environment
Year: 2013
Volume: 11
Issue: 3&4
Category: Food and Health
Pages: 420-422

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