Journal of Food, Agriculture and Environment

Role of short-chain fatty acids in modulation of gut health


Ravindra V. Kale, Akshay Swami

Recieved Date: 2022-01-24, Accepted Date: 2022-03-28


Nowadays the concept of gut health has become a major concern for the development of functional food such as prebiotics and probiotics. Prebiotics has a profound effect on the composition of the microbiota and the physiology of the gut. These are escaped from digestion in the small intestine and fermented in the colon. The selective fermentation of prebiotics by microbiota leads to the formation of short-chain fatty acids like butyrate, propionate, and acetate in the colon. The SCFA regulates the luminal pH, provides energy to colonocytes, increases mucus production, and enhances the mucosal defense function against invading pathogens, thereby it maintains gut integrity and homeostasis. The lack of prebiotic/SCFA in the colon is prone to many physiological disorders like oxidative stress, inflammation, and loss of gut defense. The modulation of SCFA in the gut within the physiological range is the only way to overcome these disorders.


Short-chain fatty acids, prebiotic, fructooligosaccharide, gut health, gut defense

Journal: Journal of Food, Agriculture and Environment
Year: 2022
Volume: 20
Issue: 2
Category: Food and Health
Pages: 19-22

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